Molecular Mechanism of an Oncogenic Mutation That Alters Membrane Targeting: Glu17Lys Modifies the PIP Lipid Specificity of the AKT1 PH Domain
Journal Article
Overview
publication date
- November 25, 2008
has subject area
- Amino Acids, Acidic - Glutamic Acid
- Amino Acids, Basic - Lysine
- Amino Acids, Diamino - Lysine
- Amino Acids, Dicarboxylic - Glutamic Acid
- Amino Acids, Essential - Lysine
- Animals
- Biochemical Phenomena - Kinetics
- Cattle
- Cell Line - 3T3 Cells
- Cell Membrane
- Cell Survival
- Diagnostic Imaging - Microscopy, Fluorescence
- Excitatory Amino Acids - Glutamic Acid
- Fibroblasts - 3T3 Cells
- Humans
- Investigative Techniques - Microscopy, Fluorescence
- Mechanical Phenomena - Kinetics
- Mice
- Mutation
- Neoplasms
- Oncogenes
- Phosphatidylinositol 4,5-Diphosphate
- Phosphatidylinositol Phosphates
- Protein Structure, Tertiary
- Protein-Serine-Threonine Kinases - Proto-Oncogene Proteins c-akt
- Proteins - Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins - Proto-Oncogene Proteins c-akt
- Substrate Specificity
has restriction
- green
Date in CU Experts
- September 6, 2013 4:37 AM
Full Author List
- Landgraf KE; Pilling C; Falke JJ
author count
- 3
citation count
- 80
published in
- Biochemistry Journal
Other Profiles
International Standard Serial Number (ISSN)
- 0006-2960
Digital Object Identifier (DOI)
Additional Document Info
start page
- 12260
end page
- 12269
volume
- 47
issue
- 47