research overview
- Regulation of epigenetic silencing by RNA and replication of chromosome telomeres.
- Contact Info
Cech, Tom
Positions
- Faculty Director, Biofrontiers Institute
- Distinguished Professor, Molecular, Cellular & Developmental Biology (MCDB)
- Distinguished Professor, Biochemistry
Research Areas
Research
keywords
- Interdisciplinary research and education
Publications
selected publications
-
book
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chapter
- Molecular Science of Fluctuations Toward Biological Functions Foreword. V-VI. 2016
- THE RNA WORLD THIRD EDITION The Nature of Modern RNA Suggests a Prebiotic RNA World Preface. Cold Spring Harbor Monograph Series. IX-X. 2006
- The RNP World. Cold Spring Harbor Monograph Series. 309-326. 2006
- Overturning the Dogma: Catalytic RNA 2001
- Building a Catalytic Active Site Using Only RNA 1999
- Structure and Mechanism of the Large Catalytic RNAs: Group I and Group II Introns and Ribonuclease P 1999
- RNA: Getting the Message 1995
- The Origin of Life and the Value of Life 1995
- Multiple Enzymatic Activities of an Intervening Sequence RNA from Tetrahymena 1987
- Viroids Contain Sequences Characteristic of Group I Introns 1987
- Ribosomal RNA Gene Expression in Tetrahymena: Transcription and RNA Splicing 1986
- Confrontational Dynamics Involved in RNA Self-Splicing 1986
- Mechanism of Self-Splicing of the Ribosomal RNA Precursor of Tetrahymena 1986
- Self-Splicing of the Ribosomal RNA Precursor of Tetrahymena 1983
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conference proceeding
- Human CST assembles into a decameric supercomplex upon binding to single-stranded telomeric DNA. Biophysical Journal. 1-2. 2022
- TERT Promoter Mutations and Cancer. The FASEB Journal. 2016
- TERT Promoter Mutations and Cancer. The FASEB Journal. 2016
- RNA as a Flexible Scaffold for Proteins: Yeast Telomerase and Beyond. Cold Spring Harbor Symposia on Quantitative Biology. 217-224. 2006
- MECHANISM AND STRUCTURE OF A CATALYTIC RNA MOLECULE. 91-110. 1993
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journal article
-
RNA-induced PRC2 inhibition depends on the sequence of bound RNA..
Nature Communications.
2026
-
Single-molecule tracking of DNMT1 in living cells reveals its cell cycle dynamics and its redistribution upon drug treatment..
Nucleic Acids Research (NAR).
2026
-
DHX36 modulates stress granule assembly independent of recruitment of mRNAs with G-quadruplex sequence motifs.
Nucleic Acids Research (NAR).
2025
-
Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication.
Nucleic Acids Research (NAR).
2025
-
Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq.
Nature Communications.
2025
-
PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner.
Molecular Cell.
3593-3595.
2024
-
Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis.
RNA: A publication of the RNA Society.
1213-1226.
2024
- Diverse RNA Structures Induce PRC2 Dimerization and Inhibit Histone Methyltransferase Activity 2024
- Reflections from Nobel laureates in chemistry. Cell Chemical Biology. 2024
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Transcription factors ERα and Sox2 have differing multiphasic DNA- and RNA-binding mechanisms.
RNA: A publication of the RNA Society.
1089-1105.
2024
-
POT1 recruits and regulates CST-Polα/primase at human telomeres.
Cell.
2024
-
Telomerase misbehaves after a breakup Suppressing telomerase action at broken DNA preserves genome integrity.
Science.
702-703.
2024
-
Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq
2023
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Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Science.
1331-1337.
2023
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Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells.
2023
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Multiple RNA- and DNA- binding proteins exhibit direct transfer of polynucleotides with implications for target- site search.
Proceedings of the National Academy of Sciences of the United States of America.
2023
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PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers.
Proceedings of the National Academy of Sciences of the United States of America.
2023
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Supplementary Figures 1-8 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
2023
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Supplementary Figures 1-8 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
2023
-
Supplementary Methods and Table S1 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
2023
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Supplementary Methods and Table S1 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
2023
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DNMT1 inhibition by pUG-fold quadruplex RNA.
RNA: A publication of the RNA Society.
346-360.
2023
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DNMT1 inhibition by pUG-fold quadruplex RNA.
RNA: A publication of the RNA Society.
346-360.
2023
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DNMT1 inhibition by pUG-fold quadruplex RNA.
RNA: A publication of the RNA Society.
346-360.
2023
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DNMT1 inhibition by pUG-fold quadruplex RNA..
RNA: A publication of the RNA Society.
346-360.
2023
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The complexity of transferring genetic information..
Molecular Cell.
2023
-
DNMT1 inhibition by pUG-fold quadruplex RNA
2022
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Reconstitution of a telomeric replicon organized by CST.
Nature.
819-+.
2022
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Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.
Proceedings of the National Academy of Sciences of the United States of America.
2022
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RNA in biological condensates INTRODUCTION.
RNA: A publication of the RNA Society.
1-2.
2022
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CST does not evict elongating telomerase but prevents initiation by ssDNA binding.
Nucleic Acids Research (NAR).
11653-11665.
2021
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Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention (vol 12, 3308, 2021).
Nature Communications.
2021
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TRIM28 is a transcriptional activator of the mutant TERT in human bladder cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2021
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Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools.
Methods.
44-58.
2021
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Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention.
Nature Communications.
2021
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Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
Nature Reviews Molecular Cell Biology.
283-298.
2021
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Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization (Feb, 10.1038/s41580-021-00328-y, 2021).
Nature Reviews Molecular Cell Biology.
299-299.
2021
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Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.
Molecular Cell.
488-+.
2021
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Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates withTERTexpression in multiple cancers.
Molecular Oncology.
2358-2374.
2020
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RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells.
Nature Genetics.
931-+.
2020
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Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA transcripts is driven by intron retention: implications for RNA-directed therapies
2020
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Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers.
Molecular Cancer Research.
1050-1062.
2020
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The structure of human CST reveals a decameric assembly bound to telomeric DNA.
Science.
1081-+.
2020
-
Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid.
Nucleic Acids Research (NAR).
2969-2981.
2020
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The cryo-EM structure of human CST reveals a two-megadalton decameric assembly bound to telomeric DNA
2019
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Regulation of histone methylation by automethylation of PRC2.
Genes & Development.
1416-1427.
2019
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Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.
Proceedings of the National Academy of Sciences of the United States of America.
18488-18497.
2019
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C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms.
RNA: A publication of the RNA Society.
935-947.
2019
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Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
Nucleic Acids Research (NAR).
8865-8875.
2018
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A Lifelong Passion for All Things Ribonucleic.
Cell.
14-17.
2018
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In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure.
1275-+.
2018
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Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits.
Genes & Development.
794-805.
2018
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Dynamics of human telomerase recruitment depend on template-telomere base pairing.
Molecular Biology of the Cell.
869-880.
2018
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Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.
Cell reports.
3700-3707.
2017
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Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.
Nature Structural & Molecular Biology.
1028-+.
2017
-
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.
eLife.
2017
-
Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.
Nature Communications.
2017
-
How do lncRNAs regulate transcription?.
Science Advances.
2017
-
Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.
Molecular Cell.
1056-+.
2017
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Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.
Genes & Development.
59-71.
2017
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Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
Cell.
1188-+.
2016
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RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure.
Cell.
1267-1279.
2016
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Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Nature Structural & Molecular Biology.
286-292.
2016
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The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.
RNA: A publication of the RNA Society.
2007-2022.
2015
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A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
Genome Biology.
2015
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Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.
Genes & Development.
2219-2224.
2015
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Protein-RNA interaction restricts telomerase from running through the stop sign.
Nature Structural & Molecular Biology.
835-836.
2015
-
Nucleic acid-binding specificity of human FUS protein.
Nucleic Acids Research (NAR).
7535-7543.
2015
-
Human telomerase: biogenesis, trafficking, recruitment, and activation.
Genes & Development.
1095-1105.
2015
-
RNA World research-still evolving.
RNA: A publication of the RNA Society.
474-475.
2015
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Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase.
Journal of Molecular Biology.
1291-1303.
2015
- Placental Expression of the lncRNA NEAT1 Increases in Preeclampsia. Reproductive Sciences. 201A-201A. 2015
- Placental Expression of the lncRNA NEAT1, and Not MENb or TncRNA, Increases With Gestation. Reproductive Sciences. 189A-189A. 2015
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TERT promoter mutations and telomerase reactivation in urothelial cancer.
Science.
1006-1010.
2015
-
Toward a Consensus on the Binding Specificity and Promiscuity of PRC2 for RNA.
Molecular Cell.
552-558.
2015
-
Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.
Journal of Cell Science.
331-341.
2015
-
Biochemical Properties and Biological Functions of FET Proteins.
Annual Review of Biochemistry.
355-379.
2015
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Academia and industry: Companies on campus..
Nature.
297-298.
2014
-
Companies on campus.
Nature.
297-298.
2014
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Identification of human TERT elements necessary for telomerase recruitment to telomeres.
eLife.
2014
-
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.
Molecular Biology of the Cell.
2571-2578.
2014
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Structure and Function of Steroid Receptor RNA Activator Protein, the Proposed Partner of SRA Noncoding RNA.
Journal of Molecular Biology.
1766-1785.
2014
-
The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones.
Cell.
77-94.
2014
-
Telomerase in Bladder Cancer: Back to a Better Future?.
European Urology.
370-371.
2014
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Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.
Nucleic Acids Research (NAR).
8565-8577.
2014
-
NAR Breakthrough Article A dimeric state for PRC2.
Nucleic Acids Research (NAR).
9236-9248.
2014
-
Inhibition of Telomerase Recruitment and Cancer Cell Death.
Journal of Biological Chemistry.
33171-33180.
2013
-
Promiscuous RNA binding by Polycomb repressive complex 2.
Nature Structural & Molecular Biology.
1250-U273.
2013
-
RNA Seeds Higher-Order Assembly of FUS Protein.
Cell reports.
918-925.
2013
-
Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
Nucleic Acids Research (NAR).
8969-8978.
2013
-
3 ' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing.
BMC Molecular Biology.
2013
-
RNA recognition by the DNA end-binding Ku heterodimer.
RNA: A publication of the RNA Society.
841-851.
2013
-
Finding the end: recruitment of telomerase to telomeres.
Nature Reviews Molecular Cell Biology.
71-+.
2013
-
How a Chemist Looks at RNA.
Angewandte Chemie International Edition.
75-78.
2013
-
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.
Genes & Development.
2690-2695.
2012
-
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nature.
285-+.
2012
-
SnapShot: Telomeres and Telomerase.
Cell.
2012
-
The RNA Worlds in Context.
Cold Spring Harbor perspectives in biology.
2012
-
RNase P branches out from RNP to protein: organelle-triggered diversification?.
Genes & Development.
1005-1009.
2012
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Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model.
Cell.
922-932.
2012
- Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.. Cell. 922-32-922-32. 2012
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DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.
Nucleic Acids Research (NAR).
235-244.
2012
- DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.. 235-44-235-44. 2012
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The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
Nature Structural & Molecular Biology.
1371-U84.
2011
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Multiple POT1-TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA.
Journal of Molecular Biology.
10-17.
2011
-
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.
Nature.
399-+.
2011
-
Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
RNA: A publication of the RNA Society.
298-311.
2011
-
Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants.
Molecular and Cellular Biology.
4965-4976.
2010
-
Engineering cis-telomerase RNAs that add telomeric repeats to themselves.
Proceedings of the National Academy of Sciences of the United States of America.
4914-4918.
2010
-
Functional interaction between telomere protein TPP1 and telomerase.
Genes & Development.
613-622.
2010
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POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.
EMBO Journal.
924-933.
2010
-
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.
Proceedings of the National Academy of Sciences of the United States of America.
651-656.
2010
-
Crawling Out of the RNA World.
Cell.
599-602.
2009
-
A natural ribozyme with 3 ',5 ' RNA ligase activity.
Nature Chemical Biology.
97-99.
2009
-
Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.
Nucleic Acids Research (NAR).
354-367.
2009
-
Evolution of Biological Catalysis: Ribozyme to RNP Enzyme.
Cold Spring Harbor Symposia on Quantitative Biology.
11-16.
2009
-
Toward predicting self-splicing and protein-facilitated splicing of group I introns.
RNA: A publication of the RNA Society.
2013-2029.
2008
-
Mutation in TERT separates processivity from anchor-site function.
Nature Structural & Molecular Biology.
871-872.
2008
-
Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.
Molecular and Cellular Biology.
4152-4161.
2008
-
Triple-helix structure in telomerase RNA contributes to catalysis.
Nature Structural & Molecular Biology.
634-640.
2008
-
On the occasion of the 25(th) anniversary of the discovery of catalytic RNA.
Biological Chemistry.
661-662.
2007
-
Local RNA structural changes induced by crystallization are revealed by SHAPE.
RNA: A publication of the RNA Society.
536-548.
2007
-
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature.
506-510.
2007
-
Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency.
RNA: A publication of the RNA Society.
1721-1737.
2006
- Crystal structure of an essential telomerase-specific domain of TERT. The FASEB Journal. A984-A984. 2006
-
Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.
RNA: A publication of the RNA Society.
387-395.
2006
-
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Nature Structural & Molecular Biology.
218-225.
2006
-
Atomic level architecture of group I introns revealed.
Trends in Biochemical Sciences.
41-51.
2006
-
RNA as a flexible scaffold for proteins: Yeast telomerase and beyond.
Cold Spring Harbor Symposia on Quantitative Biology.
217-224.
2006
-
A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro.
Nature Structural & Molecular Biology.
1072-1077.
2005
-
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
Journal of Biological Chemistry.
32069-32080.
2005
-
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Proceedings of the National Academy of Sciences of the United States of America.
10864-10869.
2005
-
Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Protein Science.
2051-2058.
2005
-
Switching human telomerase on and off with hPOT1 protein in vitro.
Journal of Biological Chemistry.
20449-20456.
2005
-
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
Journal of Biological Chemistry.
5249-5257.
2005
- Fostering innovation and discovery in biomedical research.. 1390-3-1390-3. 2005
-
Global expression changes resulting from loss of telomeric DNA in fission yeast - art. no. R1.
Genome Biology.
2005
-
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Nature Structural & Molecular Biology.
1223-1229.
2004
-
Structure of the Tetrahymena ribozyme: Base triple sandwich and metal ion at the active site.
Molecular Cell.
351-362.
2004
-
Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.
Bioscience Reports.
362-385.
2004
-
Yeast telomerase RNA: A flexible scaffold for protein subunits.
Proceedings of the National Academy of Sciences of the United States of America.
10024-10029.
2004
-
The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro.
RNA: A publication of the RNA Society.
1108-1118.
2004
-
RNA finds a simpler way.
Nature.
263-264.
2004
-
Beginning to understand the end of the chromosome.
Cell.
273-279.
2004
- Nurturing interdisciplinary research.. 1166-9-1166-9. 2004
-
Tetrahymena telomerase is active as a monomer.
Molecular Biology of the Cell.
4794-4804.
2003
-
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.
Nature.
198-203.
2003
-
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA..
Nature.
198-203.
2003
-
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.
RNA: A publication of the RNA Society.
1323-1332.
2003
-
Sequence-specific and 3′-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein α subunit.
Biochemistry.
9269-9277.
2003
-
Human POT1 facilitates telomere elongation by telomerase.
Current Biology.
942-946.
2003
-
The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.
Biochemistry.
5736-5747.
2003
-
Yeast telomerase is specialized for C/A-rich RNA templates.
Nucleic Acids Research (NAR).
1646-1655.
2003
-
Rebalancing teaching and research.
Science.
165-165.
2003
-
N-terminal domain of yeast telomerase reverse transcriptase: Recruitment of Est3p to the telomerase complex.
Molecular Biology of the Cell.
1-13.
2003
- Sharing publication-related data and materials: responsibilities of authorship in the life sciences.. 19-24-19-24. 2003
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Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe.
Biochemistry.
14560-14568.
2002
-
A bulged stem tethers Est1p to telomerase RNA in budding yeast.
Genes & Development.
2800-2812.
2002
-
Evolution of Tetrahymena ribozyme mutants with increased structural stability.
Nature Structural & Molecular Biology.
855-861.
2002
-
Human Pot1 (Protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing.
Molecular and Cellular Biology.
8079-8087.
2002
-
Ribozymes, the first 20 years.
Biochemical Society Transactions.
1162-1166.
2002
-
The chemical repertoire of natural ribozymes.
Nature.
222-228.
2002
-
In vivo selection of better self-splicing introns in Escherichia coli: The role of the P1 extension helix of the Tetrahymena intron.
RNA: A publication of the RNA Society.
647-658.
2002
-
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction..
Molecular and Cellular Biology.
2366-2374.
2002
-
Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: Evidence for product-assisted translocation.
Biochemistry.
151-161.
2002
-
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.
Biochemistry.
7005-7016.
2001
-
Pot1, the putative telomere end-binding protein in fission yeast and humans.
Science.
1171-1175.
2001
-
Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry..
Current Protocols in Nucleic Acid Chemistry.
Unit-5.1.
2001
-
Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA-solvent interactions.
Structure.
221-231.
2001
- Two RNA machines: Ribozyme and telomerase. The FASEB Journal. A57-A57. 2001
-
An early transition state for folding of the P4-P6 RNA domain.
RNA: A publication of the RNA Society.
161-166.
2001
- Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry.. Unit 5.1-Unit 5.1. 2001
- Science and business. Conflicts of interest–moving beyond disclosure.. Science. 989-989. 2001
-
Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.
EMBO Journal.
6230-6239.
2000
-
Multiple folding pathways for the P4-P6 RNA domain.
Biochemistry.
12465-12475.
2000
-
Protection of telomeres by the Ku protein in fission yeast.
Molecular Biology of the Cell.
3265-3275.
2000
-
A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.
Journal of Biological Chemistry.
24199-24207.
2000
-
Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase.
Molecular Cell.
493-499.
2000
-
Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of the United States of America.
6367-6372.
2000
-
Life at the end of the chromosome: Telomeres and telomerase.
Angewandte Chemie International Edition.
34-43.
2000
- Structural biology. The ribosome is a ribozyme.. Science. 878-9-878-9. 2000
-
Quantifying the energetic interplay of RNA tertiary and secondary structure interactions.
RNA: A publication of the RNA Society.
1665-1674.
1999
- Science at liberal arts colleges: A better education?. Daedalus. 195-216. 1999
-
Self-splicing of the Tetrahymena intron from mRNA in mammalian cells.
EMBO Journal.
6491-6500.
1999
-
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.
Genes & Development.
2863-2874.
1999
-
RNA tertiary folding monitored by fluorescence of covalently attached pyrene.
Biochemistry.
14224-14237.
1999
- Hot papers - Telomerase - Telomerase catalytic subunit homologs from fission yeast and human by T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, T.E. Cech - Comments. SCIENTIST. 14-14. 1999
-
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.
Nature.
177-180.
1999
-
In vitro selection of RNAs with increased tertiary structure stability.
RNA: A publication of the RNA Society.
1119-1129.
1999
-
Energetics and cooperativity of tertiary hydrogen bonds in RNA structure.
Biochemistry.
8691-8702.
1999
-
Telomerase and the maintenance of chromosome ends.
Current Opinion in Cell Biology.
318-324.
1999
-
In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity.
RNA: A publication of the RNA Society.
1481-1492.
1998
-
Two modes of survival of fission yeast without telomerase.
Science.
493-496.
1998
-
A preorganized active site in the crystal structure of the Tetrahymena ribozyme.
Science.
259-264.
1998
-
A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps.
RNA: A publication of the RNA Society.
1179-1185.
1998
-
Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features.
Chemistry and Biology.
539-553.
1998
-
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- RNA AS AN ENZYME. Biochemistry International. 7-14. 1989
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SPECIFICITY FOR 3',5'-LINKED SUBSTRATES IN RNA-CATALYZED RNA POLYMERIZATION.
Journal of Molecular Evolution.
480-485.
1989
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CONSERVED SEQUENCES AND STRUCTURES OF GROUP-I INTRONS - BUILDING AN ACTIVE-SITE FOR RNA CATALYSIS - A REVIEW.
Gene.
259-271.
1988
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SEQUENCE-SPECIFIC ENDORIBONUCLEASE ACTIVITY OF THE TETRAHYMENA RIBOZYME - ENHANCED CLEAVAGE OF CERTAIN OLIGONUCLEOTIDE SUBSTRATES THAT FORM MISMATCHED RIBOZYME SUBSTRATE COMPLEXES.
Biochemistry.
8924-8931.
1988
- RIBOZYMES AND THEIR MEDICAL IMPLICATIONS. Journal of the American Medical Association (JAMA). 3030-3034. 1988
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DETERMINANTS OF THE 3' SPLICE SITE FOR SELF-SPLICING OF THE TETRAHYMENA PRE-RRNA.
Genes & Development.
1439-1447.
1988
-
TELOMERIC REPEATS OF TETRAHYMENA-MALACCENSIS MITOCHONDRIAL-DNA - A MULTIMODAL DISTRIBUTION THAT FLUCTUATES ERRATICALLY DURING GROWTH.
Molecular and Cellular Biology.
4450-4458.
1988
-
DELETION OF NONCONSERVED HELICES NEAR THE 3' END OF THE RIBOSOMAL-RNA INTRON OF TETRAHYMENA-THERMOPHILA ALTERS SELF-SPLICING BUT NOT CORE CATALYTIC ACTIVITY.
Genes & Development.
652-663.
1988
-
DNA BIOCHEMISTRY - G-STRINGS AT CHROMOSOME ENDS.
Nature.
777-778.
1988
-
RNA AS AN RNA-POLYMERASE - NET ELONGATION OF AN RNA PRIMER CATALYZED BY THE TETRAHYMENA RIBOZYME.
Science.
1412-1416.
1988
-
MITOCHONDRIAL TELOMERES - SURPRISING DIVERSITY OF REPEATED TELOMERIC DNA-SEQUENCES AMONG 6 SPECIES OF TETRAHYMENA.
Cell.
367-374.
1988
-
PHYLOGENETIC-RELATIONSHIPS AND ALTERED GENOME STRUCTURES AMONG TETRAHYMENA MITOCHONDRIAL DNAS.
Nucleic Acids Research (NAR).
327-346.
1988
- BIOLOGIC CATALYSIS BY RNA. Harvey lectures. 123-144. 1988
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3-DIMENSIONAL MODEL OF THE ACTIVE-SITE OF THE SELF-SPLICING RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA.
Proceedings of the National Academy of Sciences of the United States of America.
8788-8792.
1987
-
SELF-SPLICING RNA AND AN RNA ENZYME IN TETRAHYMENA.
The Journal of protozoology.
416-417.
1987
-
TELOMERIC DNA PROTEIN INTERACTIONS OF OXYTRICHA MACRONUCLEAR DNA.
Genes & Development.
783-793.
1987
-
STRUCTURAL CONVENTIONS FOR GROUP-I INTRONS.
Nucleic Acids Research (NAR).
7217-7221.
1987
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SELECTION OF CIRCULARIZATION SITES IN A GROUP-1 IVS RNA REQUIRES MULTIPLE ALIGNMENTS OF AN INTERNAL TEMPLATE-LIKE SEQUENCE.
Cell.
951-961.
1987
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5' EXON REQUIREMENT FOR SELF-SPLICING OF THE TETRAHYMENA-THERMOPHILA PRE-RIBOSOMAL RNA AND IDENTIFICATION OF A CRYPTIC 5' SPLICE SITE IN THE 3' EXON.
Journal of Molecular Biology.
49-60.
1987
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THE CHEMISTRY OF SELF-SPLICING RNA AND RNA ENZYMES.
Science.
1532-1539.
1987
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GUANOSINE BINDING REQUIRED FOR CYCLIZATION OF THE SELF-SPLICING INTERVENING SEQUENCE RIBONUCLEIC-ACID FROM TETRAHYMENA-THERMOPHILA.
Biochemistry.
3330-3340.
1987
- RNA AS AN ENZYME. The FASEB Journal. 2020-2020. 1987
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STRUCTURES INVOLVED IN TETRAHYMENA RIBOSOMAL-RNA SELF-SPLICING AND RNA ENZYME-ACTIVITY.
Cold Spring Harbor Symposia on Quantitative Biology.
147-157.
1987
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THE TETRAHYMENA RIBOZYME ACTS LIKE AN RNA RESTRICTION ENDONUCLEASE.
Nature.
429-433.
1986
-
RNA AS AN ENZYME.
SCIENTIFIC AMERICAN.
64-&.
1986
-
ONE BINDING-SITE DETERMINES SEQUENCE SPECIFICITY OF TETRAHYMENA PRE-RIBOSOMAL-RNA SELF-SPLICING, TRANSSPLICING, AND RNA ENZYME-ACTIVITY.
Cell.
207-216.
1986
-
THE TELOMERES OF THE LINEAR MITOCHONDRIAL-DNA OF TETRAHYMENA THERMOPHILA CONSIST OF 53-BP TANDEM REPEATS.
Cell.
873-883.
1986
-
RIBOZYME INHIBITORS - DEOXYGUANOSINE AND DIDEOXYGUANOSINE ARE COMPETITIVE INHIBITORS OF SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID PRECURSOR.
Biochemistry.
4473-4477.
1986
-
THE TETRAHYMENA INTERVENING SEQUENCE RIBONUCLEIC-ACID ENZYME IS A PHOSPHOTRANSFERASE AND AN ACID-PHOSPHATASE.
Biochemistry.
4478-4482.
1986
-
MECHANISM OF RECOGNITION OF THE 5' SPLICE SITE IN SELF-SPLICING GROUP-I INTRONS.
Nature.
86-89.
1986
-
A MODEL FOR THE RNA-CATALYZED REPLICATION OF RNA.
Proceedings of the National Academy of Sciences of the United States of America.
4360-4363.
1986
-
NEW REACTIONS OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA AND THE MECHANISM OF SELF-SPLICING.
Journal of Molecular Biology.
143-165.
1986
-
ROLE OF CONSERVED SEQUENCE ELEMENT-9L AND ELEMENT-2 IN SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL-RNA PRECURSOR.
Cell.
167-176.
1986
-
THE GENERALITY OF SELF-SPLICING RNA - RELATIONSHIP TO NUCLEAR MESSENGER-RNA SPLICING.
Cell.
207-210.
1986
-
THE INTERVENING SEQUENCE RNA OF TETRAHYMENA IS AN ENZYME.
Science.
470-475.
1986
-
BIOLOGICAL CATALYSIS BY RNA.
Annual Review of Biochemistry.
599-629.
1986
- THE INTERVENING SEQUENCE RNA OF TETRAHYMENA IS AN ENZYME. Journal of Cellular Biochemistry. 88-88. 1986
-
SITES OF CIRCULARIZATION OF THE TETRAHYMENA RIBOSOMAL-RNA IVS ARE DETERMINED BY SEQUENCE AND INFLUENCED BY POSITION AND SECONDARY STRUCTURE.
Nucleic Acids Research (NAR).
8389-8408.
1985
-
COUPLING OF TETRAHYMENA RIBOSOMAL-RNA SPLICING TO BETA-GALACTOSIDASE EXPRESSION IN ESCHERICHIA-COLI.
Science.
719-722.
1985
-
INTERMOLECULAR EXON LIGATION OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - OLIGONUCLEOTIDES CAN FUNCTION AS 5' EXONS.
Cell.
431-437.
1985
-
OLIGOMERIZATION OF INTERVENING SEQUENCE RNA MOLECULES IN THE ABSENCE OF PROTEINS.
Science.
1060-1064.
1985
-
REACTIONS OF THE INTERVENING SEQUENCE OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID PRECURSOR - PH-DEPENDENCE OF CYCLIZATION AND SITE-SPECIFIC HYDROLYSIS.
Biochemistry.
6211-6218.
1985
-
REVERSIBILITY OF CYCLIZATION OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - IMPLICATION FOR THE MECHANISM OF SPLICE SITE CHOICE.
Cell.
639-648.
1985
-
SECONDARY STRUCTURE OF THE CIRCULAR FORM OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - A TECHNIQUE FOR RNA STRUCTURE-ANALYSIS USING CHEMICAL PROBES AND REVERSE-TRANSCRIPTASE.
Proceedings of the National Academy of Sciences of the United States of America.
648-652.
1985
-
SELF-CATALYZED CYCLIZATION OF THE INTERVENING SEQUENCE RNA OF TETRAHYMENA - INHIBITION BY INTERCALATING DYES.
Nucleic Acids Research (NAR).
7741-7758.
1985
-
SELF-CATALYZED CYCLIZATION OF THE INTERVENING SEQUENCE RNA OF TETRAHYMENA - INHIBITION BY METHIDIUMPROPYL.EDTA AND LOCALIZATION OF THE MAJOR DYE BINDING-SITES.
Nucleic Acids Research (NAR).
7759-7779.
1985
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SELF-SPLICING RNA - IMPLICATIONS FOR EVOLUTION.
International review of cytology.
3-22.
1985
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SEQUENCE REQUIREMENTS FOR SELF-SPLICING OF THE TETRAHYMENA-THERMOPHILA PRE-RIBOSOMAL RNA.
Nucleic Acids Research (NAR).
1871-1889.
1985
-
A LABILE PHOSPHODIESTER BOND AT THE LIGATION JUNCTION IN A CIRCULAR INTERVENING SEQUENCE RNA.
Science.
574-578.
1984
-
CHROMATIN STRUCTURE AT THE REPLICATION ORIGINS AND TRANSCRIPTION-INITIATION REGIONS OF THE RIBOSOMAL-RNA GENES OF TETRAHYMENA.
Cell.
933-942.
1984
-
CHROMATIN STRUCTURE OF THE MOLECULAR ENDS OF OXYTRICHA MACRONUCLEAR DNA - PHASED NUCLEOSOMES AND A TELOMERIC COMPLEX.
Cell.
501-510.
1984
-
DNA - PROTEIN INTERACTIONS IN THE DROSOPHILA-VIRILIS MITOCHONDRIAL CHROMOSOME.
Nucleic Acids Research (NAR).
1991-1999.
1984
-
SPECIFIC INTERACTION BETWEEN THE SELF-SPLICING RNA OF TETRAHYMENA AND ITS GUANOSINE SUBSTRATE - IMPLICATIONS FOR BIOLOGICAL CATALYSIS BY RNA.
Nature.
820-826.
1984
-
AUTOCATALYTIC CYCLIZATION OF AN EXCISED INTERVENING SEQUENCE RNA IS A CLEAVAGE LIGATION REACTION.
Nature.
578-583.
1983
-
DIFFERENT NUCLEOSOME SPACING IN TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF THE RIBOSOMAL-RNA GENE IN TETRAHYMENA-THERMOPHILA.
Nucleic Acids Research (NAR).
2093-2109.
1983
-
FATE OF AN INTERVENING SEQUENCE RIBONUCLEIC-ACID - EXCISION AND CYCLIZATION OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID INTERVENING SEQUENCE INVIVO.
Biochemistry.
2390-2397.
1983
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RNA SPLICING - 3 THEMES WITH VARIATIONS.
Cell.
713-716.
1983
- SECONDARY STRUCTURE OF A SELF-SPLICING RNA. The FASEB Journal. 1884-1884. 1983
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SECONDARY STRUCTURE OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - STRUCTURAL HOMOLOGY WITH FUNGAL MITOCHONDRIAL INTERVENING SEQUENCES.
Proceedings of the National Academy of Sciences of the United States of America.
3903-3907.
1983
-
TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF TETRAHYMENA RIBOSOMAL GENE CHROMATIN HAVE DIFFERENT ACCESSIBILITIES TO MICROCOCCAL NUCLEASE.
Nucleic Acids Research (NAR).
2077-2091.
1983
-
SELF-SPLICING RNA - AUTO-EXCISION AND AUTO-CYCLIZATION OF THE RIBOSOMAL-RNA INTERVENING SEQUENCE OF TETRAHYMENA.
Cell.
147-157.
1982
-
THE INTERVENING SEQUENCE EXCISED FROM THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA CONTAINS A 5'-TERMINAL GUANOSINE RESIDUE NOT ENCODED BY THE DNA.
Nucleic Acids Research (NAR).
2823-2838.
1982
- TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF THE RIBOSOMAL-RNA GENE OF TETRAHYMENA EXHIBIT DIFFERENT CHROMATIN STRUCTURES. The FASEB Journal. 514-514. 1982
- TRANSCRIPTION AND SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA. 171-204. 1982
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ALKALINE GEL-ELECTROPHORESIS OF DEOXYRIBONUCLEIC-ACID PHOTOREACTED WITH TRIMETHYLPSORALEN - RAPID AND SENSITIVE DETECTION OF INTERSTRAND CROSS-LINKS.
Biochemistry.
1431-1437.
1981
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.
Cell.
487-496.
1981
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.
Cell.
487-496.
1981
-
REPLICATION OF THE EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILIA.
Nucleic Acids Research (NAR).
3531-3543.
1981
- SPLICING OF THE RIBOSOMAL-RNA PRECURSOR AND CYCLIZATION OF THE EXCISED INTERVENING SEQUENCE RNA IN NUCLEI OF TETRAHYMENA. The FASEB Journal. 1651-1651. 1981
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THE INTERVENING SEQUENCE OF THE RIBOSOMAL-RNA PRECURSOR IS CONVERTED TO A CIRCULAR RNA IN ISOLATED-NUCLEI OF TETRAHYMENA.
Cell.
467-476.
1981
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CHROMATIN STRUCTURE OF THE RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILA AS ANALYZED BY TRIMETHYLPSORALEN CROSSLINKING INVIVO.
Journal of Molecular Biology.
395-416.
1980
-
DNA-PROTEIN INTERACTIONS IN THE DROSOPHILA-MELANOGASTER MITOCHONDRIAL GENOME AS DEDUCED FROM TRIMETHYLPSORALEN CROSSLINKING PATTERNS.
Proceedings of the National Academy of Sciences of the United States of America.
4118-4122.
1980
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR IN NUCLEI OF TETRAHYMENA.
Cell.
331-338.
1980
-
An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives.
Biochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis.
342-360.
1979
-
LOCALIZATION OF TRANSCRIBED REGIONS ON EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILA BY R-LOOP MAPPING.
Proceedings of the National Academy of Sciences of the United States of America.
5051-5055.
1979
- Chromatin structure in living cells.. 191-8-191-8. 1978
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Electron microscopy of DNA crosslinked with trimethylpsoralen: a probe for chromatin structure.
Biochemistry.
5313-5321.
1977
-
Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure.
Cell.
631-640.
1977
- Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.. 2644-8-2644-8. 1976
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ORGANIZATION OF HIGHLY REPEATED SEQUENCES IN MOUSE MAIN-BAND DNA.
Journal of Molecular Biology.
227-256.
1976
-
PARTIAL DENATURATION OF MOUSE DNA IN PREPARATIVE CSCL DENSITY GRADIENTS AT ALKALINE PH.
Biochemistry.
1865-1873.
1976
-
STUDY OF DNA DENATURATION IN ULTRACENTRIFUGE.
Biopolymers.
1591-1613.
1976
-
ELECTRON-MICROSCOPIC STUDY OF MOUSE FOLDBACK DNA.
Cell.
429-446.
1975
- Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA.. 329-39-329-39. 1974
- Characterization of the most rapidly renaturing sequences in mouse main-band DNA.. 299-325-299-325. 1973
-
RNA-induced PRC2 inhibition depends on the sequence of bound RNA..
Nature Communications.
2026
Background
education and training
- Ph.D., University of California-Berkeley 1975
- B.A., Grinnell College 1970
awards and honors
International Activities
geographic focus
- Australia Country
- Austria Country
- Belgium Country
- Canada Country
- China Country
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