A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4
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Animals
Animals, Inbred Strains - Mice, Inbred C57BL
Anti-Inflammatory Agents - Anti-Inflammatory Agents, Non-Steroidal
Antigens, Bacterial - Lipopolysaccharides
Antirheumatic Agents - Anti-Inflammatory Agents, Non-Steroidal
Autacoids - Dinoprostone
Biochemical Phenomena - Signal Transduction
Cell Physiological Phenomena - Signal Transduction
Cells - Microglia
Cells, Cultured
Endotoxins - Lipopolysaccharides
Fatty Acids, Unsaturated - Dinoprostone
Female
Glycoconjugates - Lipopolysaccharides
Humans
Hydrocarbons, Aromatic - Minocycline
Lipids - Lipopolysaccharides
Mice
Mice - Mice, Inbred C57BL
Nervous System - Microglia
Nervous System Diseases - Hyperalgesia
Nervous System Physiological Phenomena - Touch
Peripheral Nervous System Diseases - Neuralgia
Physical Stimulation
Polycyclic Compounds - Minocycline
Polysaccharides - Lipopolysaccharides
Psychological Phenomena - Touch
Rats
Rats, Wistar
Sciatic Nerve
Sensory System Agents - Anti-Inflammatory Agents, Non-Steroidal
Signs and Symptoms - Hyperalgesia
Signs and Symptoms - Neuralgia
Toll-Like Receptor 2
Toll-Like Receptor 4
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Date in CU Experts
Full Author List
Bastos LFS; Godin AM; Zhang Y; Jarussophon S; Ferreira BCS; Machado RR; Maier SF; Konishi Y; de Freitas RP; Fiebich BL
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