Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects
Journal Article
Overview
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Animal Population Groups - Mice, Transgenic
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Animals
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Animals, Inbred Strains - Mice, Inbred C57BL
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Behavior - Motor Activity
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Binding Sites
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Carrier Proteins - Receptors, Nicotinic
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Cerebral Cortex
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Cerebral Cortex - Hippocampus
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Chemically-Induced Disorders - Tobacco Use Disorder
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Cloning, Molecular
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Corpus Striatum
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DNA-Binding Proteins - Proto-Oncogene Proteins c-fos
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Diagnostic Imaging - Radionuclide Imaging
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Diagnostic Techniques, Radioisotope - Radionuclide Imaging
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Drug Therapy - Self Administration
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Environment and Public Health - Analysis of Variance
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Female
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Gene Expression
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Genetic Engineering
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Health Care Evaluation Mechanisms - Analysis of Variance
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Humans
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Investigative Techniques - Analysis of Variance
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Limbic System - Hippocampus
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Male
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Membrane Proteins - Receptors, Nicotinic
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Membrane Proteins - Receptors, Nicotinic
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Mental Disorders - Tobacco Use Disorder
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Mice
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Mice - Mice, Inbred C57BL
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Mice - Mice, Transgenic
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Multigene Family
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Musculoskeletal Physiological Phenomena - Motor Activity
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Nerve Tissue Proteins
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Nervous System Diseases - Seizures
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Nuclear Proteins - Proto-Oncogene Proteins c-fos
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Pharmacological Phenomena - Dose-Response Relationship, Drug
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Phenotype
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Proto-Oncogene Proteins - Proto-Oncogene Proteins c-fos
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Pyridines - Nicotine
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Receptors, Cell Surface - Receptors, Nicotinic
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Receptors, Cholinergic - Receptors, Nicotinic
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Signs and Symptoms - Seizures
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Solanaceous Alkaloids - Nicotine
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Therapeutics - Self Administration
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Toxicological Phenomena - Dose-Response Relationship, Drug
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Transcription Factors - Proto-Oncogene Proteins c-fos
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Date in CU Experts
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September 9, 2013 11:05 AM
Full Author List
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Gallego X; Molas S; Amador-Arjona A; Marks MJ; Robles N; Murtra P; Armengol L; Fernandez-Montes RD; Gratacos M; Pumarola M
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